Bcl-2 anticorps (pThr56)
Aperçu rapide pour Bcl-2 anticorps (pThr56) (ABIN317972)
Antigène
Voir toutes Bcl-2 (BCL2) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- pThr56
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Specificité
- This antibody detects endogenous levels of BCL-2 protein only when phosphorylated at Thr56.
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Purification
- Affinity Chromatography using epitope-specific immunogen.
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Indications d'application
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ELISA: 1: 20000approx. 1: 40000. IP: 1: 50approx. 1: 200. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Restrictions
- For Research Use only
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Concentration
- 1.0 mg/mL
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Buffer
- Phosphate Buffered Saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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Autre désignation
- Bcl-2
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Sujet
- Bcl2 is an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of Bcl2, such as in the case of translocation of Bcl2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C terminal ends.Synonyms: Apoptosis regulator Bcl-2, B-Cell CLL/lymphoma 2, BCL2, Bcl-2 alpha
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Poids moléculaire
- approx. 26 kDa
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ID gène
- 596
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NCBI Accession
- NP_000624
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UniProt
- P10415
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Pathways
- Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Antigène
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