ERN1 anticorps (C-Term)

N° du produit ABIN318702

Cet anticorps anti-ERN1 Polyclonal Lapin (ABIN318702) détecte spécifiquement ERN1 dans WB, IF et IHC (fro). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ERN1 anticorps (C-Term) (ABIN318702)

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERN1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-ERN1 anticorps

Épitope: C-Term

Specificité: This antibody recognises inositol-requiring kinase 1 precursor (IRE1p).

Purification: Affinity Chromatography

Immunogène: A 16 amino acid peptide near the carboxy terminus of Human IRE1p

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1 - 2 μg/mL (detects a band of approximately 110 kDa in A-20 cell lysate).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur ERN1

Antigène: ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))

Autre désignation: ERN1 / IRE1

Sujet: Inositol-requiring kinase 1 precursor (IRE1p) is a 108 kDa serine-threonine kinase/endoribonuclease also known as ERN1. It is an endoplasmic reticulum (ER) transmembrane protein, normally bound to the ER molecular chaperones GRP78 and GRP94. At times of ER stress, due to accumulation of unfolded proteins, IRE1p becomes dissociated from the chaperones, which allows it to activate the un-folded protein transcriptional response (UPR). In the mammalian genome, there are two homologs Ire1alpha and Ire1beta. Ire1alpha is expressed in all cells and tissues, Ire1beta expression is primarily restricted to intestinal epithelial cells.Synonyms: Endoplasmic reticulum-to-nucleus signaling 1, IRE1a, IRE1p, Inositol-requiring protein 1, Ire1-alpha, Serine/threonine-protein kinase/endoribonuclease IRE1

ID gène: 2081

NCBI Accession: NP_001424

UniProt: O75460

Pathways: ER-Nucleus Signaling, Unfolded Protein Response