SYT1 anticorps (Thr199, Thr202)

N° du produit ABIN319341

Détail du produit anti-SYT1 anticorps

Antigène: SYT1 (Synaptotagmin I (SYT1))

Épitope: Thr199, Thr202

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYT1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody detects endogenous levels of total Synaptotagmin I/II protein.

Purification: Immunoaffinity Chromatography using epitope-specific immunogen.

Immunogène: The antiserum was produced against synthesized non-phosphopeptide derived from human Synaptotagmin I/II around the phosphorylation site of Threonine 202/199 (R-K-Tp-L-N).

Information d'application

Indications d'application: Western blot: 1/500approx. 1/1000. Immunofluorescence: 1/100approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at-20 °C.

Détails sur SYT1

Antigène: SYT1 (Synaptotagmin I (SYT1))

Autre désignation: Synaptotagmin-1 (SYT1 Produits)

Synonymes: anticorps P65, anticorps SVP65, anticorps SYT, anticorps CG3139, anticorps D. Syt I, anticorps DSYT, anticorps DSYT2, anticorps DSypt, anticorps DSyt, anticorps Dmel\\CG3139, anticorps Droso1, anticorps Dsyt2, anticorps SYT I, anticorps SYT1, anticorps Syt, anticorps Syt 1, anticorps Syt I, anticorps Syt-1, anticorps SytI, anticorps dSYT, anticorps dsyt1, anticorps dsytI, anticorps l(2)23AB1, anticorps l(2)23Ba, anticorps l(2)k05909, anticorps syt, anticorps syt 1, anticorps syt I, anticorps syt-1, anticorps syt1, anticorps sytI, anticorps AW124717, anticorps G630098F17Rik, anticorps Syti, anticorps GB20036, anticorps DKFZP459P193, anticorps svp65, anticorps p65, anticorps wu:fj41c01, anticorps wu:fk56d05, anticorps zgc:92899, anticorps synaptotagmin 1, anticorps Synaptotagmin 1, anticorps synaptotagmin I, anticorps synaptotagmin-1, anticorps synaptotagmin, p65, anticorps synaptotagmin Ia, anticorps synaptotagmin 1 L homeolog, anticorps SYT1, anticorps Syt1, anticorps Tsp_06980, anticorps Tsp_08220, anticorps syt1, anticorps LOC100533340, anticorps syt1a, anticorps syt1.L

Sujet: Synaptotagmin 1 is a 60 kDa member of the synaptotagmin family, expressed in membranes of synaptic vesicles in rostral, phylogenetically younger brain regions and in some endocrine tissues. Ca2+ is bound by synaptogamin whose C2 domains then bind phospholipids, trafficking vesicles to the synaptic membrane and exocytosis. This results in fast synchronous neurotransmitter release. Synaptotagmin also binds neurexins, syntaxin and AP2 independently of Ca2+ binding. Phosphorylation of synaptotagmin by protein kinases is thought to modulate its activity. Synaptotagmin 2 belongs to the synaptotagmin family of multi-domained, integral membrane proteins of synaptic vesicles which are thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.Synonyms: SYT1/SYT2, Synaptotagmin I/II

ID gène: 6857

NCBI Accession: NP_001129277

UniProt: P21579

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport