ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100, Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS with 0.09 % (W/V) sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
Antigène
STAT5B
(Signal Transducer and Activator of Transcription 5B (STAT5B))
anticorps STAT5, anticorps stat5, anticorps STAT5A, anticorps STAT5B, anticorps signal transducer and activator of transcription 5B, anticorps signal transducer and activator of transcription 5B S homeolog, anticorps Signal transducer and activator of transcription 5B, anticorps STAT5B, anticorps Stat5b, anticorps stat5b.S, anticorps LOC490969, anticorps sta5b, anticorps LOC100566752, anticorps LOC100052954
Sujet
STAT5b is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.Synonyms: STAT-5B, Signal transducer and activator of transcription 5B