HIRA anticorps (Middle Region)

N° du produit ABIN358780

Cet anticorps Lapin Polyclonal détecte spécifiquement HIRA dans WB et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour HIRA anticorps (Middle Region) (ABIN358780)

Antigène: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HIRA est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Détail du produit anti-HIRA anticorps

Épitope: Middle Region

Specificité: This antibody reacts to HIRA.

Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogène: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human HIRA.

Isotype: Ig Fraction

Information d'application

Indications d'application: ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur HIRA

Antigène: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Autre désignation: HIRA / TUPLE1

Sujet: HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.Synonyms: DGCR1, HIR, HIR histone cell cycle regulation defective homolog A, TUP1-like enhancer of split protein 1

ID gène: 7290, 9606

UniProt: P54198

Pathways: Chromatin Binding