LRP2 anticorps

N° du produit ABIN360955

Cet anticorps Souris Monoclonal détecte spécifiquement LRP2 dans IHC (p) et IF. Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour LRP2 anticorps (ABIN360955)

Antigène: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LRP2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Clone: CD7D5

Détail du produit anti-LRP2 anticorps

Specificité: This antibody recognizes Megalin/gp330.

Purification: Protein G Chromatography

Immunogène: Purified Human Megalin.

Isotype: IgG1

Information d'application

Indications d'application: Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 6.0 without preservatives or stabilizers

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody at -20 °C.

Détails sur LRP2

Antigène: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Autre désignation: LRP2

Sujet: Megalin, also called Lipoprotein receptor-related protein-2 (LRP2) or glycoprotein 330, is a 600- kDa transmembrane protein belonging to the LDL-receptor family. Members of this receptor family are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Megalin was first discovered in 1982 as the pathogenic antigen of Heymann nephritis. The complete cDNA sequences have been characterized for rat and human Megalin. The protein contains a single transmembrane domain, is known to act as an endocytic receptor and is expressed primarily on the apical membrane domain of epithelial cells. Both the protein and its mRNA have been identified in human parathyroid cells, placental cytotrophoblasts and epididymal epithelial cells. The protein is also expressed in mammary epithelia, thyroid follicular cells, yolk sacs, the ciliary body of the eye, the intestinal brush border, the male reproductive tract, uterus and oviduct, and gallbladder epithelium. In addition, immortalised foetal rat alveolar pretype II cells, adult rat type II pneumocytes and human type II cells have all been reported to express megalin. It has been proposed that in adult lung megalin may be important in supplying vitamin E to type II pneumocytes. Specifically, Megalin mediates the uptake of apolipoprotein J, which is a binding protein for the beta-Amyloid peptide, a peptide implicated in Alzheimer's disease. It is also involved in renal uptake of Angiotensin and the reabsorption of various molecules including calcium, vitamin B12 and vitamin D.Synonyms: Glycoprotein 330, LRP-2, Low-density lipoprotein receptor-related protein 2, Megalin

ID gène: 4036

NCBI Accession: NP_004516

UniProt: P98164

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport