LRP2 anticorps (C-Term)

N° du produit ABIN1537368

Détail du produit anti-LRP2 anticorps

Antigène: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Épitope: AA 4626-4655, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This LRP2 (Megalin) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4626-4655 amino acids from the C-terminal region of human LRP2 (Megalin).

Clone: RB1834

Isotype: Ig Fraction

Information d'application

Indications d'application: IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur LRP2

Antigène: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Autre désignation: LRP2 (Megalin) (LRP2 Produits)

Synonymes: anticorps im:680590, anticorps lrp2, anticorps dbs, anticorps gp330, anticorps megalin, anticorps DBS, anticorps GP330, anticorps AI315343, anticorps AW536255, anticorps D230004K18Rik, anticorps Gp330, anticorps Megalin, anticorps LDL receptor related protein 2, anticorps low density lipoprotein receptor-related protein 2a, anticorps low density lipoprotein receptor-related protein 2, anticorps low-density lipoprotein receptor-related protein 2, anticorps LDL receptor related protein 2 L homeolog, anticorps LRP2, anticorps lrp2a, anticorps LRP2.3, anticorps lrp2.L, anticorps LOC100183506, anticorps lrp2, anticorps Lrp2

Sujet: Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration (1). Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes (2). All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family (3).

Poids moléculaire: 521958

ID gène: 4036

NCBI Accession: NP_004516

UniProt: P98164

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport