GRIN1/NMDAR1 anticorps (AA 1-564)

N° du produit ABIN361405

Détail du produit anti-GRIN1/NMDAR1 anticorps

Antigène: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Épitope: AA 1-564

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GRIN1/NMDAR1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Specificité: Specific for the ~120k NR1 subunit of the NMDA receptor. The antibody has been directly tested for reactivity in Western blots in rat and mouse tissues.

Réactivité croisée: Souris, Rat (Rattus)

Purification: Culture supernatant

Immunogène: Fusion protein containing amino acids 1-564 of the NR1 subunit

Clone: R1JHL

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 IP: 3 µg per 200 µg lysate

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized

Stock: -20 °C

Références pour anticorps anti-GRIN1/NMDAR1 (ABIN361405)

Quillinan, Grewal, Deng, Shimizu, Yonchek, Strnad, Traystman, Herson: "Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia." dans: Neuroscience, Vol. 284, pp. 555-65, (2014) (PubMed).

Hicklin, Wu, Radcliffe, Freund, Goebel-Goody, Correa, Proctor, Lombroso, Browning: "Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 16, pp. 6650-5, (2011) (PubMed).

Davies, Goebel-Goody, Coultrap, Browning: "Long term synaptic depression that is associated with GluR1 dephosphorylation but not alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization." dans: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33138-46, (2008) (PubMed).

Zhang, Dong, Zhang, Ichinose, Wu, Culley, Crosby, Tanzi, Xie: "Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 28, Issue 17, pp. 4551-60, (2008) (PubMed).

Détails sur GRIN1/NMDAR1

Antigène: GRIN1/NMDAR1 (GRIN1) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 1 (GRIN1))

Autre désignation: GRIN1 (GRIN1 Produits)

Synonymes: anticorps GluN1, anticorps MRD8, anticorps NMDA1, anticorps NMDAR1, anticorps NR1, anticorps nmda1, anticorps nmdar1, anticorps GB19253, anticorps GRIN1, anticorps NMD-R1, anticorps Z16, anticorps GluRdelta1, anticorps GluRzeta1, anticorps M100174, anticorps Nmdar, anticorps Rgsc174, anticorps NMDAR1.1, anticorps zgc:152678, anticorps glutamate ionotropic receptor NMDA type subunit 1, anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 1 S homeolog, anticorps NMDA receptor 1, anticorps G protein-regulated inducer of neurite outgrowth 1, anticorps glutamate receptor, ionotropic, NMDA1 (zeta 1), anticorps glutamate receptor, ionotropic, N-methyl D-aspartate 1a, anticorps GRIN1, anticorps grin1.S, anticorps grin1, anticorps Grin1, anticorps Nmdar1, anticorps Gprin1, anticorps grin1a

Sujet: The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and a-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1-subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Anti-NMDAR, NR1 Subunit Western blot of 10 ug of rat hippocampal (Hipp) lysate showing specific immunolabeling of the ~120k NR1 subunit of the NMDA receptor.

Poids moléculaire: '120 kDa

ID gène: 24408

UniProt: P35439

Pathways: Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity