GABRB2 anticorps (Cytoplasmic Loop)

N° du produit ABIN361447

Détail du produit anti-GABRB2 anticorps

Antigène: GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))

Épitope: Cytoplasmic Loop

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRB2 est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for the ~55k ß2-subunit of the GABAA receptor in Western blots.

Réactivité croisée: Souris, Rat (Rattus)

Homologie: canine, human, non-human primate

Purification: Antigen Affinity Purified

Immunogène: Fusion protein from the cytoplasmic loop of the beta 2 subunit

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Références pour anticorps anti-GABRB2 (ABIN361447)

Antflick, Hampson: "Modulation of glutamate release from parallel fibers by mGlu4 and pre-synaptic GABA(A) receptors." dans: Journal of neurochemistry, Vol. 120, Issue 4, pp. 552-63, (2012) (PubMed).

Détails sur GABRB2

Antigène: GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))

Autre désignation: GABRB2 (GABRB2 Produits)

Synonymes: anticorps GABRB2, anticorps GARB2, anticorps fj59e04, anticorps gabaabeta2, anticorps wu:fj59e04, anticorps zgc:136311, anticorps GABARB, anticorps AI834970, anticorps C030002O17Rik, anticorps C030021G16Rik, anticorps Gabrab2, anticorps Gabrb-2, anticorps gamma-aminobutyric acid type A receptor beta2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, beta 2, anticorps gamma-aminobutyric acid type A receptor beta 2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit beta 2, anticorps GABRB2, anticorps gabrb2, anticorps Gabrb2

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003). Anti-GABAA-Receptor, (2-Subunit Western blot of 7 (g of rat cerebellum (Cb) showing specific immunolabeling of the ~55k ß2-subunit of the GABAA-R.

Poids moléculaire: '55 kDa

ID gène: 25451

UniProt: P63138

Pathways: Sensory Perception of Sound, Synaptic Membrane