ABL1/2 anticorps (pTyr393, pTyr429)

N° du produit ABIN362460

Détail du produit anti-ABL1/2 anticorps

Antigène: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Épitope: pTyr393, pTyr429

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABL1/2 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Specificité: The antibody detects endogenous level of ABL1/2 only when phosphorylated at tyrosine393/429.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogène: Peptide sequence around phosphorylation site of pTyr393, 429 (D-T-Y (p) -T-A) derived from Human ABL1, 2. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotype: IgG

Information d'application

Indications d'application: Western blotting: 1:500-1:1000
Immunohistochemistry: 1:50-1:100
Immunofluorescence: 1:100-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur ABL1/2

Antigène: ABL1/2 (ABL1/ABL2) (Abelson Murine Leukemia Viral Oncogene Homolog 1/2 (ABL1/ABL2))

Autre désignation: ABL1/2 (ABL1/ABL2 Produits)

Synonymes: anticorps CABL, anticorps ABLL, anticorps cb272, anticorps ABL proto-oncogene 2, non-receptor tyrosine kinase, anticorps c-abl oncogene 2, non-receptor tyrosine kinase, anticorps ABL2, anticorps abl2

Sujet: Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.

Poids moléculaire: 210 kDa

NCBI Accession: NP_001129, NP_005148

UniProt: P42684