IRAK4 anticorps (AA 38-54, AA 120-136)

N° du produit ABIN372431

L’anticorps Lapin Polyclonal anti-IRAK4 a été validé pour WB et IHC (p). Il convient pour détecter IRAK4 dans des échantillons de Humain et Souris.

Aperçu rapide pour IRAK4 anticorps (AA 38-54, AA 120-136) (ABIN372431)

Antigène: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRAK4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-IRAK4 anticorps

Épitope: AA 38-54, AA 120-136

Specificité: This antibody recognizes Interleukin 1 Receptor-Associated Kinase 4 (IRAK4).

Réactivité croisée (Details): Species reactivity (expected):Human.
Species reactivity (tested):Mouse.

Purification: Protein G Chromatography.

Immunogène: A mixture of synthetic peptides containing amino acids 38-54 and 120-136 of Mouse IRAK-4.

Isotype: IgG

Information d'application

Indications d'application: Western blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.2 % Gelatin as stabilizer and 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur IRAK4

Antigène: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Autre désignation: IRAK4

Sujet: The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. IL-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members. The cytoplasmic domains of TIR proteins interact with the adapter protein, MyD88. MyD88 then recruits IRAKs (IRAK-1, -2, and M), which in turn interact with other adapter molecules, such as TRAF6 to activate NF-kB and MAPK pathways. Recently, a new member of this family, IRAK-4 has been identified. IRAK-4 may act as an upstream activator of IRAK-1. IRAK-4 is important for LPS activation of TLRS. Mice lacking IRAK-4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges.Synonyms: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64

ID gène: 51135

NCBI Accession: NP_001107654

UniProt: Q9NWZ3

Pathways: Signalisation NF-kappaB, Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades