GABRA6 anticorps (Cytoplasmic Loop)

N° du produit ABIN372635

Détail du produit anti-GABRA6 anticorps

Antigène: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Épitope: Cytoplasmic Loop

Reactivité: Humain, Rat, Souris, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRA6 est non-conjugé

Application: Western Blotting (WB), Dot Blot (DB)

Specificité: Specific for the ~57k Alpha-6 subunit of the GABAA Receptor in Western blots of Rat brain membrane fractions. Also recognizes the alpha-6 subunit of GABAA-R in Bovine, Human amnd Mouse brain extracts. Does not recognizes GABAA-R subunits as reactivity is eliminated in alpha-6 knockout brain.

Purification: Affinity Chromatography.

Immunogène: Fusion protein from the cytoplasmic loop of the Alpha-6 subunit of Rat GABAA Receptor.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur GABRA6

Antigène: GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))

Autre désignation: GABAA Receptor alpha 6 (GABRA6 Produits)

Synonymes: anticorps LOC100224835, anticorps GABRA6, anticorps Gabra-6, anticorps alpha6, anticorps si:dkey-217k23.1, anticorps zgc:73148, anticorps gamma-aminobutyric acid type A receptor alpha 6 subunit, anticorps gamma-aminobutyric acid type A receptor alpha6 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6, anticorps gamma-aminobutyric acid (GABA) A receptor, alpha 6a, anticorps Gabra6, anticorps GABRA6, anticorps gabra6a

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different Alpha-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003).Synonyms: GABRA-6, GABRA6, Gamma-Aminobutyric Acid Receptor subunit Alpha-6

ID gène: 29708

NCBI Accession: NP_068613

UniProt: P30191

Pathways: Synaptic Membrane