Cytohesin 2 anticorps (N-Term)

N° du produit ABIN374897

Détail du produit anti-Cytohesin 2 anticorps

Antigène: Cytohesin 2 (CYTH2)

Épitope: N-Term

Reactivité: Humain, Rat, Souris, Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp Cytohesin 2 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to ARNO / cytohesin 2.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Canine.
Species reactivity (tested):Human, Rat.

Purification: Affinity chromatography

Immunogène: Peptide with sequence EDGVYEPPDLTP-C, from the N Terminus of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/32000. Western Blot: 0.5 - 1.5 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Cytohesin 2

Antigène: Cytohesin 2 (CYTH2)

Autre désignation: Cytohesin 2 (CYTH2 Produits)

Synonymes: anticorps ARNO, anticorps CTS18, anticorps CTS18.1, anticorps PSCD2, anticorps PSCD2L, anticorps SEC7L, anticorps Sec7p-L, anticorps Sec7p-like, anticorps CLM2, anticorps Pscd2, anticorps Arno, anticorps Sec7, anticorps Sec7B, anticorps pscd2, anticorps MGC84366, anticorps CYTH2, anticorps cyth2, anticorps cytohesin 2, anticorps cytohesin-2, anticorps cytohesin 2 L homeolog, anticorps si:dkey-283b15.4, anticorps CYTH2, anticorps PTRG_08834, anticorps Cyth2, anticorps cyth2.L, anticorps cyth2, anticorps si:dkey-283b15.4

Sujet: The ADP-ribosylation factor (Arf) family comprises a group of structurally and functionally conserved 21 kDa proteins, which are members of the Ras superfamily of regulatory GTP-binding proteins. Arf is involved in intracellular protein traffic to and within the Golgi complex. Arf has a number of disparate activities including maintenance of organelle integrity, assembly of coat proteins, as a co-factor for cholera toxin and as an activator of phospholipase D. Like other small GTPases, Arf is found to be active when bound to GTP and inactive when bound to GDP. Arf's activation is dependent upon guanine nucleotide exchange factors (GEFs) which increase the rate of exchange of bound GDP with GTP. All GEFs have a highly conserved Sec7 domain. GEF activity lies in the Sec7 domain and this activity has been shown to be inhibited by the fungal metabolite brefeldin-A (BFA). A small group of GEFs which are insensitive to brefeldin-A (BFA) include cytohesin-1 (B2-1), cytohesin-2 (ARNO), cytohesin-3 (ARNO3), and cytohesin-4. All cytohesins function in the cell periphery and contain a pleckstrin homology (PH) domain. The PH domain has been shown to interact with phosphatidylinositol 3,4,5-triphosphate and is believed to promote membrane targeting of the cytohesins. Recruitment of the cytohesins to the membranes can occur in response to tyrosine kinase receptor activation. This response appears to require the activation of phosphatidylinositol 3-kinase (PI 3-kinase).Synonyms: ARF exchange factor, ARF nucleotide-binding site opener, ARNO, CYTH2, PH, PSCD2, PSCD2L, SEC7 and coiled-coil domain-containing protein 2

ID gène: 9266, 9606

UniProt: Q99418