MC2R anticorps (N-Term)

N° du produit ABIN374914

Détail du produit anti-MC2R anticorps

Antigène: MC2R (Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R))

Épitope: N-Term

Reactivité: Humain

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp MC2R est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody reacts to MC2R / ACTHR.

Purification: Affinity chromatography

Immunogène: Peptide with sequence ENINNTARNNSDC, from the N Terminus of the protein sequence

Information d'application

Indications d'application: Peptide ELISA: 1/32000. Western Blot: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur MC2R

Antigène: MC2R (Melanocortin 2 Receptor (Adrenocorticotropic Hormone) (MC2R))

Autre désignation: MC2-R (MC2R Produits)

Synonymes: anticorps ACTHR, anticorps ACTH-R, anticorps MC2-R, anticorps MC2R, anticorps MC2, anticorps melanocortin 2 receptor, anticorps MC2R, anticorps Mc2r, anticorps mc2r

Sujet: MC2 receptor is the second member of the five known melanocortin receptors (MCRs) belonging to the rhodopsin-like family of G protein-coupled receptors (GPCRs). These five MCRs form a unique family of GPCRs, marked by their unusually short coding sequence and the absence of highly conserved amino acid residues or motifs common to most GPCRs. All MCRs signal through the cyclic adenosine 3', 5'-monophosphate (cAMP) pathway. MC2 receptor is the smallest MCR and the smallest known GPCR (297 amino acids). It exclusively binds the adrenocorticotrophic hormone (ACTH) and this binding plays a pivotal role in homeostasis, metabolism, and stress response. In contrast, the other four MCRs are activated by both ACTH and melanocyte-stimulating hormones (MSHs and mainly alpha-MSH). The MC2 receptor is predominantly expressed in the adrenal gland but is also found in the murine adipocyte. Mutations in MC2R can result in familial glucocorticoid deficiency.Synonyms: ACTH receptor, ACTH-R, ACTHR, Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, MC2R

ID gène: 4158, 9606

UniProt: Q01718

Pathways: cAMP Metabolic Process