NFkB anticorps (pSer536)

N° du produit ABIN389601

Cet anticorps anti-NFkB est un anticorps Lapin Polyclonal détectant NFkB dans WB. Adapté pour Humain et Souris. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour NFkB anticorps (pSer536) (ABIN389601)

Antigène: NFkB (Nuclear Factor kappa B (NFkB))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NFkB est non-conjugé

Application: Western Blotting (WB)

Clone: RB5212

Détail du produit anti-NFkB anticorps

Épitope: pSer536

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This NFKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S536 of human NFKB.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-NFkB (ABIN389601)

Li, Lu, Yu, Han, Wang, Mao, Shen, Wang, Tang, Li, Song: "miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-κB/COX-2 activation." dans: Chemico-biological interactions, Vol. 277, pp. 33-42, (2017) (PubMed).

Wang, Cai, Shao, Siddiqui, Palanisamy, Li, Ren, Ayala, Ittmann: "Activation of NF-{kappa}B by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4." dans: Cancer research, Vol. 71, Issue 4, pp. 1325-33, (2011) (PubMed).

Détails sur NFkB

Antigène: NFkB (Nuclear Factor kappa B (NFkB))

Autre désignation: NFKB

Sujet: NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).

Poids moléculaire: 60219

ID gène: 5970

NCBI Accession: NP_001138610, NP_001230913, NP_068810

UniProt: Q04206

Pathways: Ubiquitin Proteasome Pathway, S100 Proteins