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NFkB anticorps (pSer536)

NFkB Reactivité: Humain DB Hôte: Lapin Polyclonal RB22552 unconjugated
N° du produit ABIN650886
  • Antigène Voir toutes NFkB Anticorps
    NFkB (Nuclear Factor kappa B (NFkB))
    Épitope
    • 9
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer536
    Reactivité
    • 27
    • 7
    • 3
    • 3
    • 1
    Humain
    Hôte
    • 30
    • 4
    Lapin
    Clonalité
    • 29
    • 5
    Polyclonal
    Conjugué
    • 19
    • 6
    • 4
    • 2
    • 2
    • 2
    Cet anticorp NFkB est non-conjugé
    Application
    • 27
    • 16
    • 15
    • 8
    • 7
    • 7
    • 5
    • 2
    • 1
    • 1
    Dot Blot (DB)
    Homologie
    M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This NF kappa B Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S536 of human NF kappa B.
    Clone
    RB22552
    Isotype
    Ig Fraction
    Top Product
    Discover our top product NFkB Anticorps primaire
  • Indications d'application
    DB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    NFkB (Nuclear Factor kappa B (NFkB))
    Autre désignation
    NF kappa B (NFkB Produits)
    Synonymes
    anticorps EBP-1, anticorps KBF1, anticorps NF-kB1, anticorps NF-kappa-B, anticorps NF-kappaB, anticorps NFKB-p105, anticorps NFKB-p50, anticorps NFkappaB, anticorps p105, anticorps p50, anticorps NF-kB, anticorps NF-KB1, anticorps NF-kappaB1, anticorps p50/p105, anticorps nuclear factor kappa B subunit 1, anticorps nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105, anticorps NFKB1, anticorps Nfkb1
    Sujet
    NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
    Poids moléculaire
    60219
    ID gène
    5970
    NCBI Accession
    NP_001138610, NP_001230913, NP_068810
    UniProt
    Q04206
    Pathways
    Ubiquitin Proteasome Pathway, S100 Proteins
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