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NFkB anticorps (pSer536)

NFkB Reactivité: Humain, Souris WB Hôte: Lapin Polyclonal RB5212 unconjugated
N° du produit ABIN389601
  • Antigène Voir toutes NFkB Anticorps
    NFkB (Nuclear Factor kappa B (NFkB))
    Épitope
    • 9
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer536
    Reactivité
    • 27
    • 6
    • 3
    • 3
    • 1
    Humain, Souris
    Hôte
    • 30
    • 4
    Lapin
    Clonalité
    • 29
    • 5
    Polyclonal
    Conjugué
    • 19
    • 6
    • 4
    • 2
    • 2
    • 2
    Cet anticorp NFkB est non-conjugé
    Application
    • 26
    • 16
    • 15
    • 8
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This NFKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S536 of human NFKB.
    Clone
    RB5212
    Isotype
    Ig Fraction
    Top Product
    Discover our top product NFkB Anticorps primaire
  • Indications d'application
    WB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Li, Lu, Yu, Han, Wang, Mao, Shen, Wang, Tang, Li, Song: "miR-221/222 promote cancer stem-like cell properties and tumor growth of breast cancer via targeting PTEN and sustained Akt/NF-κB/COX-2 activation." dans: Chemico-biological interactions, Vol. 277, pp. 33-42, (2017) (PubMed).

    Wang, Cai, Shao, Siddiqui, Palanisamy, Li, Ren, Ayala, Ittmann: "Activation of NF-{kappa}B by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4." dans: Cancer research, Vol. 71, Issue 4, pp. 1325-33, (2011) (PubMed).

  • Antigène
    NFkB (Nuclear Factor kappa B (NFkB))
    Autre désignation
    NFKB (NFkB Produits)
    Synonymes
    anticorps EBP-1, anticorps KBF1, anticorps NF-kB1, anticorps NF-kappa-B, anticorps NF-kappaB, anticorps NFKB-p105, anticorps NFKB-p50, anticorps NFkappaB, anticorps p105, anticorps p50, anticorps NF-kB, anticorps NF-KB1, anticorps NF-kappaB1, anticorps p50/p105, anticorps nuclear factor kappa B subunit 1, anticorps nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105, anticorps NFKB1, anticorps Nfkb1
    Sujet
    NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
    Poids moléculaire
    60219
    ID gène
    5970
    NCBI Accession
    NP_001138610, NP_001230913, NP_068810
    UniProt
    Q04206
    Pathways
    Ubiquitin Proteasome Pathway, S100 Proteins
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