MLLT6 anticorps (C-Term)

N° du produit ABIN390132

Détail du produit anti-MLLT6 anticorps

Antigène: MLLT6 (Myeloid/lymphoid Or Mixed-lineage Leukemia, Translocated To, 6 (MLLT6))

Épitope: AA 1056-1086, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLLT6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This MLLT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1056-1086 amino acids from the C-terminal region of human MLLT6.

Clone: RB2251-2252

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur MLLT6

Antigène: MLLT6 (Myeloid/lymphoid Or Mixed-lineage Leukemia, Translocated To, 6 (MLLT6))

Autre désignation: MLLT6 (MLLT6 Produits)

Synonymes: anticorps AF17, anticorps MLLT6, PHD finger containing, anticorps MLLT6

Sujet: Band 11q23 chromosome locations are associated with approximately 10 % of patients with acute lymphoblastic leukemia (ALL) and more than 5 % of patients with acute myeloid leukemia (AML). 11q23 translocation associated leukemias typically jointly express lymphoid and myeloid markers and exhibit poor prognosis. The gene at 11q23 involved in the translocations is known by multiple names, including ALL1, HRX, MLL, and TRX1. One of the more infrequent translocations, t(11,17)(q23,q21), MLLT6, encodes a protein of 1,093 amino acids, containing a leucine-zipper dimerization motif 3-prime to the fusion point and a cysteine-rich domain at the end terminus that can be arranged in 3 zinc fingers. MMLT6 contains amino acid runs associated with domains involved in transcriptional repression or activation. It has been proposed that MLLT6 represses truncated ALL1 function or inhibits function of the normal protein in leukemic cells.

Poids moléculaire: 112048

ID gène: 4302

NCBI Accession: NP_005928

UniProt: P55198