ZMIZ1 anticorps (C-Term)

N° du produit ABIN390174

Détail du produit anti-ZMIZ1 anticorps

Antigène: ZMIZ1 (Zinc Finger, MIZ-Type Containing 1 (ZMIZ1))

Épitope: AA 1038-1067, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZMIZ1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This RAI17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1038-1067 amino acids from the C-terminal region of human RAI17.

Clone: RB1963

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-ZMIZ1 (ABIN390174)

Lan, Lan, Chang, Zhang, Liu, Vikash, Wang, Huang, Wang, Zhou, Chen, Zhao: "Identification of Two Additional Susceptibility Loci for Inflammatory Bowel Disease in a Chinese Population." dans: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 41, Issue 5, pp. 2077-2090, (2017) (PubMed).

Pinnell, Yan, Cho, Keeley, Murai, Liu, Alarcon, Qin, Wang, Kuick, Elenitoba-Johnson, Maillard, Samuelson, Cierpicki, Chiang: "The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia." dans: Immunity, Vol. 43, Issue 5, pp. 870-83, (2015) (PubMed).

Rakowski, Garagiola, Li, Decker, Caruso, Jones, Kuick, Cierpicki, Maillard, Chiang: "Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias." dans: Cancer research, Vol. 73, Issue 2, pp. 930-41, (2013) (PubMed).

Détails sur ZMIZ1

Antigène: ZMIZ1 (Zinc Finger, MIZ-Type Containing 1 (ZMIZ1))

Autre désignation: RAI17 (ZMIZ1 Produits)

Synonymes: anticorps miz, anticorps rai17, anticorps zimz1, anticorps zimp10, anticorps hzimp10, anticorps MIZ, anticorps RAI17, anticorps TRAFIP10, anticorps ZIMP10, anticorps hZIMP10, anticorps BC065120, anticorps E330020C23, anticorps ENSMUSG00000072684, anticorps Gm10397, anticorps I920194n01, anticorps Rai17, anticorps Zimp10, anticorps wu:fb80e10, anticorps zgc:175159, anticorps zmiz1, anticorps zinc finger MIZ-type containing 1, anticorps zinc finger, MIZ-type containing 1, anticorps zinc finger, MIZ-type containing 1a, anticorps ZMIZ1, anticorps zmiz1, anticorps Zmiz1, anticorps zmiz1a

Sujet: Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.

Poids moléculaire: 115483

ID gène: 57178

NCBI Accession: NP_065071

UniProt: Q9ULJ6