Caspase 8 anticorps (C-Term)

N° du produit ABIN390474

Cet anticorps anti-Caspase 8 est un anticorps Lapin Polyclonal détectant Caspase 8 dans WB et FACS. Adapté pour Humain et Souris. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour Caspase 8 anticorps (C-Term) (ABIN390474)

Antigène: Caspase 8 (CASP8)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 8 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB18993

Détail du produit anti-Caspase 8 anticorps

Épitope: AA 432-461, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CASP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 432-461 amino acids from the C-terminal region of human CASP8.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:2000. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-Caspase 8 (ABIN390474)

Lin, Huang, Lin, Lin: "p-Cresol mediates autophagic cell death in renal proximal tubular cells." dans: Toxicology letters, Vol. 234, Issue 1, pp. 20-9, (2015) (PubMed).

Détails sur Caspase 8

Antigène: Caspase 8 (CASP8)

Autre désignation: CASP8

Sujet: CASP8 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases.

Poids moléculaire: 55391

ID gène: 841

NCBI Accession: NP_001073593, NP_001073594, NP_001219, NP_203519, NP_203520, NP_203522

UniProt: Q14790

Pathways: Apoptose, Caspase Cascade in Apoptosis, Signalisation TLR, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades