Activin A Receptor Type IB/ALK-4 anticorps (AA 134-164)

N° du produit ABIN392232

Cet anticorps anti-Activin A Receptor Type IB/ALK-4 est un anticorps Lapin Polyclonal détectant Activin A Receptor Type IB/ALK-4 dans WB et FACS. Adapté pour Humain et Souris.

Aperçu rapide pour Activin A Receptor Type IB/ALK-4 anticorps (AA 134-164) (ABIN392232)

Antigène: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Activin A Receptor Type IB/ALK-4 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB03514

Détail du produit anti-Activin A Receptor Type IB/ALK-4 anticorps

Épitope: AA 134-164

Homologie: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Activin A Receptor Type IB (ACVR1B) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-164 amino acids from the Central region of human Activin A Receptor Type IB (ACVR1B).

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur Activin A Receptor Type IB/ALK-4

Antigène: Activin A Receptor Type IB/ALK-4 (ACVR1B) (Activin A Receptor, Type IB (ACVR1B))

Autre désignation: Activin A Receptor Type IB (ACVR1B)

Sujet: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The gene for ACVR1B (activin A type IB receptor) is composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

Poids moléculaire: 56807

ID gène: 91

NCBI Accession: NP_004293, NP_064732, NP_064733

UniProt: P36896