PTPN5 anticorps (N-Term)

N° du produit ABIN392843

Détail du produit anti-PTPN5 anticorps

Antigène: PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))

Épitope: AA 168-198, N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTPN5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This STEP / PTPN5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-198 amino acids from the N-terminal region of human STEP / PTPN5.

Clone: RB00604

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur PTPN5

Antigène: PTPN5 (Protein tyrosine Phosphatase, Non-Receptor Type 5 (Striatum-Enriched) (PTPN5))

Autre désignation: STEP / PTPN5 (PTPN5 Produits)

Synonymes: anticorps STEP, anticorps Step, anticorps PTPSTEP, anticorps protein tyrosine phosphatase, non-receptor type 5, anticorps ptpn5, anticorps PTPN5, anticorps Ptpn5

Sujet: STEP (striatum-enriched phosphatase) is a neural-specific protein-tyrosine phosphatase, first isolated from the rat brain. The 537-amino acid predicted human protein as isolated from cDNA sequences is between 85 and 90 % identical to the mouse and rat sequences. In rat neuronal cell cultures, glutamate-mediated activation of N-methyl-D-aspartate (NMDA) receptors leads to the rapid but transient phosphorylation of extracellular signal-related kinase-2 (ERK2). NMDA-mediated influx of calcium, activates the calcium-dependent phosphatase calcineurin and the resulting dephosphorylation and activation of STEP. STEP then inactivatea ERK2 through tyrosine dephosphorylation and blocks translocation of the kinase to the nucleus. STEP plays a significant role in regulating the ERK activation and downstream signaling in neurons.

Poids moléculaire: 63538

ID gène: 84867

NCBI Accession: NP_001035059, NP_001265165, NP_001265167, NP_001265168, NP_008837, NP_116170

UniProt: P54829