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ATR anticorps (Internal Region)

ATR Reactivité: Humain, Souris, Chien, Poisson, Singe, Rat, Xenopus laevis WB, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN401401
  • Antigène Voir toutes ATR Anticorps
    ATR (Ataxia Telangiectasia and Rad3 Related (ATR))
    Épitope
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    Humain, Souris, Chien, Poisson, Singe, Rat, Xenopus laevis
    Hôte
    • 5
    • 2
    Lapin
    Clonalité
    • 5
    • 2
    Polyclonal
    Conjugué
    • 7
    Cet anticorp ATR est non-conjugé
    Application
    • 6
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificité
    This antibody is specific for ATR protein.
    Réactivité croisée (Details)
    Species reactivity (expected):Mouse, Rat, Monkey, Canine, Fish, Xenopus.
    Species reactivity (tested):Human.
    Purification
    Affinity chromatography
    Immunogène
    Synthetic peptide corresponding to an internal region of human ATR protein
    Isotype
    IgG
    Top Product
    Discover our top product ATR Anticorps primaire
  • Indications d'application
    ELISA: 1/15,000 - 1/70,000. Western Blot: 1/1,000 - 1/5,000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.28 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    -20 °C
  • Antigène
    ATR (Ataxia Telangiectasia and Rad3 Related (ATR))
    Autre désignation
    ATR / FRP1 (ATR Produits)
    Synonymes
    anticorps ATR, anticorps si:dkey-231j24.1, anticorps FCTCS, anticorps FRP1, anticorps MEC1, anticorps SCKL, anticorps SCKL1, anticorps XATR, anticorps frp1, anticorps mec1, anticorps sckl, anticorps sckl1, anticorps ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, anticorps ATATR, anticorps ATRAD3, anticorps Ataxia telangiectasia-mutated and RAD3-related, anticorps MHK7.5, anticorps MHK7_5, anticorps ataxia telangiectasia and Rad3 related, anticorps ATR serine/threonine kinase, anticorps ATR serine/threonine kinase L homeolog, anticorps Ataxia telangiectasia-mutated and RAD3-like protein, anticorps Atr, anticorps ATR, anticorps atr, anticorps atr.L
    Sujet
    Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR activates checkpoint signaling upon genotoxic stresses, such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR is a member of the DNA-PK kinase family and is closely related to ATM and DNAPK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes, including histone deacetylases (HDAC1, HDAC2 and CHD4). ATR is known to phosphorylate BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and TP53/p53 which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. ATR is a nuclear protein, but can also be found in PML nuclear bodies in certain cell types. ATR is recruited to chromatin during Sphase and redistributes to discrete nuclear foci upon DNA damage, hypoxia or replication fork stalling.Synonyms: Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, Serine/threonine-protein kinase ATR
    ID gène
    545
    NCBI Accession
    NP_001175
    UniProt
    Q13535
    Pathways
    Signalisation p53, Apoptose, Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus
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