THRA anticorps (Isoform 1, N-Term)

N° du produit ABIN401406

Détail du produit anti-THRA anticorps

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Épitope: Isoform 1, N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp THRA est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts with Human THRA protein. A BLAST analysis was used to suggest cross-reactivity with THRA from Mouse, Human and Rat based on a 100 % homology with the immunizing sequence. Cross-reactivity with THRA from other sources has not been determined.

Purification: Immunoaffinity Chromatography

Immunogène: Synthetic peptide corresponding to a region near the amino terminus of Human THRA isoform 1 protein . Genename: THRA

Isotype: IgG

Information d'application

Indications d'application: ELISA: 1/650,000. Western Blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.89 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide, None

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur THRA

Antigène: THRA (Thyroid Hormone Receptor, alpha (THRA))

Autre désignation: THRA / ERBA1 (THRA Produits)

Synonymes: anticorps AR7, anticorps CHNG6, anticorps EAR7, anticorps ERB-T-1, anticorps ERBA, anticorps ERBA1, anticorps NR1A1, anticorps THRA1, anticorps THRA2, anticorps c-ERBA-1, anticorps C-ERBA-ALPHA, anticorps TRalpha, anticorps c-erba, anticorps erba, anticorps nr1a1-A, anticorps thra-A, anticorps thra1, anticorps TR[a]1, anticorps nr1a1, anticorps thra, anticorps thral, anticorps tra, anticorps tra1, anticorps wu:fb59g07, anticorps Thra1, anticorps 6430529J03Rik, anticorps AW259572, anticorps Erba, anticorps Nr1a1, anticorps Rvr, anticorps T3R[a], anticorps T3Ralpha, anticorps Thra2, anticorps C-ERBA ALPHA1, anticorps Thra, anticorps fTHRalphaA, anticorps nr1a1-a, anticorps thyroid hormone receptor, alpha, anticorps thyroid hormone receptor, alpha L homeolog, anticorps thyroid hormone receptor alpha a, anticorps thyroid hormone receptor alpha, anticorps thyroid hormone receptor alpha-A, anticorps THRA, anticorps thra.L, anticorps thraa, anticorps Thra, anticorps tr-alpha, anticorps LOC109641414

Sujet: Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodothyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. This antibody recognizes THRA isoform 1. Isoform 1 has a distinct C-terminus compared to isoform 2.Synonyms: C-erbA-alpha, EAR-7, EAR7, NR1A1, Nuclear receptor subfamily 1 group A member 1, THRA1, THRA2, Thyroid hormone receptor alpha, c-erbA-1

ID gène: 7067

NCBI Accession: NP_001177847

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development