TIMELESS anticorps (N-Term)

N° du produit ABIN410144

L’anticorps Lapin Polyclonal anti-TIMELESS a été validé pour WB, ELISA et IHC. Il convient pour détecter TIMELESS dans des échantillons de Humain.

Aperçu rapide pour TIMELESS anticorps (N-Term) (ABIN410144)

Antigène: TIMELESS (Timeless Homolog (TIMELESS))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TIMELESS est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-TIMELESS anticorps

Épitope: N-Term

Specificité: Reacts with human 138 kDa protein

Réactivité croisée: Souris, Rat (Rattus)

Réactivité croisée (Details): Cross reacts with proteins from mouse, rat and other species.

Purification: Antiserum

Immunogène: Synthetic peptide derived from Nter domain of human hTIM protein

Isotype: IgG

Information d'application

Indications d'application:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- IHC : 1/50 to 1/200 - WB : 1/100 to 1/1 000

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Must be reconstituted in distilled water.

Stock: 4 °C/-20 °C

Stockage commentaire: Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Date de péremption: 24 months

Détails sur TIMELESS

Antigène: TIMELESS (Timeless Homolog (TIMELESS))

Autre désignation: Protein Timeless Homolog (hTIM)

Sujet: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

UniProt: Q9UNS1

Pathways: Protein targeting to Nucleus, Photoperiodism