RBCK1 anticorps (AA 251-350)
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- Antigène Voir toutes RBCK1 Anticorps
- RBCK1 (RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1))
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Épitope
- AA 251-350
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Reactivité
- Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RBCK1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Souris
- Homologie
- Human,Rat,Dog,Cow,Sheep,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human RBCK1/HBV associated factor 4
- Isotype
- IgG
- Top Product
- Discover our top product RBCK1 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- RBCK1 (RanBP-Type and C3HC4-Type Zinc Finger Containing 1 (RBCK1))
- Autre désignation
- RBCK1 (RBCK1 Produits)
- Synonymes
- anticorps RBCK1, anticorps C20orf18, anticorps HOIL-1, anticorps HOIL1, anticorps RBCK2, anticorps RNF54, anticorps UBCE7IP3, anticorps XAP3, anticorps XAP4, anticorps ZRANB4, anticorps C20ORF18, anticorps AL033326, anticorps HOIL-1L, anticorps UIP28, anticorps Ubce7ip3, anticorps Pkcbpb15, anticorps zgc:91964, anticorps SHANK-associated RH domain interactor, anticorps RANBP2-type and C3HC4-type zinc finger containing 1, anticorps ranBP-type and C3HC4-type zinc finger-containing protein 1, anticorps RanBP-type and C3HC4-type zinc finger containing 1, anticorps SHARPIN, anticorps RBCK1, anticorps LOC100411512, anticorps Rbck1, anticorps rbck1
- Sujet
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Synonyms: XAP3, XAP4, HOIL1, PBMEI, PGBM1, RBCK2, RNF54, HOIL-1, ZRANB4, C20orf18, UBCE7IP3, RanBP-type and C3HC4-type zinc finger-containing protein 1, HBV-associated factor 4, Heme-oxidized IRP2 ubiquitin ligase 1, Hepatitis B virus X-associated protein 4, RING finger protein 54, Ubiquitin-conjugating enzyme 7-interacting protein 3, RBCK1
Background: E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types.
- ID gène
- 10616
- UniProt
- Q9BYM8
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