YY1 anticorps

N° du produit ABIN4915222

Détail du produit anti-YY1 anticorps

Antigène: YY1 (YY1 Transcription Factor (YY1))

Reactivité: Humain, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp YY1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Réactivité croisée: Humain, Singe, Rat

Purification: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: Purified His-tagged YY1 protein was used to produced this monoclonal antibody.

Clone: 3C6

Isotype: IgG2a

Information d'application

Indications d'application: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur YY1

Antigène: YY1 (YY1 Transcription Factor (YY1))

Autre désignation: YY1 (YY1 Produits)

Synonymes: anticorps yy1-a, anticorps FIII, anticorps MGC83714, anticorps yy1l, anticorps zgc:64207, anticorps YY1, anticorps LOC494431, anticorps xyy1, anticorps delta, anticorps nf-e1, anticorps ucrbp, anticorps yin-yang-1, anticorps LOC100304682, anticorps ino80s, anticorps yy1, anticorps DELTA, anticorps INO80S, anticorps NF-E1, anticorps UCRBP, anticorps YIN-YANG-1, anticorps AW488674, anticorps fb59g10, anticorps wu:fa16g07, anticorps wu:fb59g10, anticorps YY1 transcription factor L homeolog, anticorps YY1 transcription factor b, anticorps YY1 transcription factor, anticorps transcriptional repressor protein YY1, anticorps YY1 transcription factor S homeolog, anticorps YY1 transcription factor a, anticorps YY2 transcription factor, anticorps yy1.L, anticorps yy1b, anticorps YY1, anticorps yy1, anticorps LOC100304682, anticorps yy1.S, anticorps Yy1, anticorps yy1a, anticorps YY2

Sujet:

Synonyms: DELTA, NF-E1, UCRBP, INO80S, YIN-YANG-1, Transcriptional repressor protein YY1, Delta transcription factor, INO80 complex subunit S, Yin and yang 1, YY-1, YY1

Background: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3', some genes have been shown to contain a longer binding motif allowing enhanced binding, the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. Acts synergistically with the SMAD1 and SMAD4 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair, proposed to target the INO80 complex to YY1-responsive elements.

ID gène: 7528

UniProt: P25490