MYD88 anticorps (AA 176-280)

N° du produit ABIN492527

L’anticorps anti-MYD88 Monoclonal Souris est utilisé pour la détection de MYD88 dans des échantillons de Humain et Souris. Il a été validé pour WB, IHC (p) et EIA.

Aperçu rapide pour MYD88 anticorps (AA 176-280) (ABIN492527)

Antigène: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MYD88 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: 2E9C2

Détail du produit anti-MYD88 anticorps

Épitope: AA 176-280

Specificité: Recognizes MyD88.

Attributs du produit: Synonyms: Myeloid differentiation primary response protein MyD88

Purification: Immunoaffinity Chromotography.

Immunogène: Recombinant protein corresponding to amino acids 176 to 280 of Human MyD88(AAC50954).

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: MyD88 antibody can be used for detection of MyD88 at 2-4 μg/mL. Positive Control: Whole cell lysate from EL4 cells. Immunohistochemistry: 2.5 μg/mL
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur MYD88

Antigène: MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))

Autre désignation: MYD88

Sujet: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues. Additional NamesSynonyms: Myeloid differentiation primary response protein MyD88

ID gène: 4615

UniProt: Q99836

Pathways: Signalisation NF-kappaB, Signalisation TLR, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades