ORAI3 anticorps (C-Term)

N° du produit ABIN492535

Cet anticorps Souris Monoclonal détecte spécifiquement ORAI3 dans WB, IHC (p) et EIA. Il présente une réactivité avec des échantillons de Humain et Rat.

Aperçu rapide pour ORAI3 anticorps (C-Term) (ABIN492535)

Antigène: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ORAI3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: 2H2G9

Détail du produit anti-ORAI3 anticorps

Épitope: C-Term

Specificité: Recognizes ORAI3. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE, these may represent post-translationally modified ORAI3.

Attributs du produit: Synonyms: TMEM142C, ORAI-3, Transmembrane Protein 142C

Purification: Immunoaffinity Chromotography.

Immunogène: A 19 amino acid peptide from near the carboxy terminus of Human ORAI3

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: ORAI3 antibody can be used for detection of ORAI3 at 2-4 μg/mL. Immunohistochemistry: 2.5 μg/mL. Positive Control: Rat spleen tissue lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur ORAI3

Antigène: ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))

Autre désignation: ORAI3

Sujet: Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2 (5). Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter.Synonyms: ORAI-3, TMEM142C, Transmembrane Protein 142C

ID gène: 93129

UniProt: Q9BRQ5