IRAK1 anticorps (AA 618-712)

N° du produit ABIN492548

L’anticorps anti-IRAK1 Monoclonal Souris est utilisé pour la détection de IRAK1 dans des échantillons de Humain et Souris. Il a été validé pour WB, IHC (p) et EIA.

Aperçu rapide pour IRAK1 anticorps (AA 618-712) (ABIN492548)

Antigène: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IRAK1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: 8F1A7

Détail du produit anti-IRAK1 anticorps

Épitope: AA 618-712

Specificité: Recognizes IRAK1 (618-712).

Attributs du produit: Synonyms: IRAK-1, IRAK, Interleukin-1 receptor-associated kinase 1

Purification: Immunoaffinity Chromatography.

Immunogène: Recombinant protein corresponding to amino acids 618-712 of Human IRAK.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: IRAK antibody can be used for detection of IRAK at 1-2 μg/mL. Positive Control: Mouse Liver Lysate. Immunohistochemistry: 5 μg/mL. Positive Control: Rat Liver Tissue.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur IRAK1

Antigène: IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))

Autre désignation: IRAK1

Sujet: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-kB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).Synonyms: IRAK, IRAK-1, Interleukin-1 receptor-associated kinase 1

ID gène: 3654

UniProt: P51617

Pathways: Signalisation NF-kappaB, Signalisation TLR, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades