CD3 epsilon anticorps (Cytoplasmic Domain)

N° du produit ABIN4949516

Cet anticorps anti-CD3 epsilon Monoclonal Souris (Clone PC3-188A) (ABIN4949516) détecte spécifiquement CD3 epsilon dans FACS, WB et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CD3 epsilon anticorps (Cytoplasmic Domain) (ABIN4949516)

Antigène: CD3 epsilon (CD3E)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD3 epsilon est non-conjugé

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Clone: PC3-188A

Détail du produit anti-CD3 epsilon anticorps

Épitope: AA 156-168, Cytoplasmic Domain

Fonction: CD3e Antibody / Cytoplasmic domain (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Amino acids 156-168 (cytoplasmic domain) from human CD3 epsilon chain were used as the immunogen for the CD3e antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the CD3e antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the CD3e antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur CD3 epsilon

Antigène: CD3 epsilon (CD3E)

Autre désignation: CD3e

Sujet: Recognizes the epsilon chain of CD3, a protein which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28 kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.

UniProt: P07766

Pathways: TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway