Major Histocompatibility Complex Class I C (HLA-C) anticorps

Détails pour le produit réf. ABIN4951309
Antigène
  • D6S204
  • HLA-JY3
  • HLC-C
  • PSORS1
  • major histocompatibility complex, class I, C
  • HLA-C
Reactivité
Humain, Souris, Rat (Rattus)
71
8
2
1
1
1
1
Hôte
Lapin
66
5
Clonalité
Polyclonal
Conjugué
Inconjugué
8
8
7
3
3
2
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
52
37
10
6
5
4
3
3
1
Options
Immunogène Amino acids EYWDRETQKYKRQAQADRVNLRKLR of human HLA-C were used as the immunogen for the HLA-C antibody.
Isotype IgG
Purification Antigen affinity
Antigène
Autre désignation HLA-C (HLA-C Antibody Extrait)
Sujet HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.
UniProt U5YBW8
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Indications d'application Optimal dilution of the HLA-C antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,ICC: 0.5-1 μg/mL
Restrictions For Research Use only
Buffer 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock -20 °C
Stockage commentaire After reconstitution, the HLA-C antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Images (Fournisseur)
Image no. 1 for anti-Major Histocompatibility Complex Class I C (HLA-C) antibody (ABIN4951309) Western blot testing of 1) human HeLa, 2) human A549, 3) human U87, 4) rat brain and ...
Image no. 2 for anti-Major Histocompatibility Complex Class I C (HLA-C) antibody (ABIN4951309) IHC testing of FFPE rat intestine with HLA-C antibody. HIER: Boil the paraffin sectio...
Image no. 3 for anti-Major Histocompatibility Complex Class I C (HLA-C) antibody (ABIN4951309) IHC testing of FFPE mouse intestine with HLA-C antibody. HIER: Boil the paraffin sect...
Image no. 4 for anti-Major Histocompatibility Complex Class I C (HLA-C) antibody (ABIN4951309) ICC testing of HeLa cells with HLA-C antibody.
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