HLA-C anticorps (C-Term)

N° du produit ABIN3043843

Détail du produit anti-HLA-C anticorps

Antigène: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Épitope: AA 38-62, C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HLA-C est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for MHC class I antigen(HLA-C) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.

Séquence: EYWDRETQKY KRQAQADRVN LRKLR

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for MHC class I antigen(HLA-C) detection. Tested with WB, IHC-P, ICC in Human,Mouse,Rat.
Gene Name: major histocompatibility complex, class I, C
Protein Name: MHC class I antigen

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human HLA-C(38-62aa EYWDRETQKYKRQAQADRVNLRKLR).

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for HLA-C is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Détails sur HLA-C

Antigène: HLA-C (Major Histocompatibility Complex Class I C (HLA-C))

Autre désignation: HLA-C (HLA-C Produits)

Synonymes: anticorps D6S204, anticorps HLA-JY3, anticorps HLC-C, anticorps PSORS1, anticorps major histocompatibility complex, class I, C, anticorps HLA-C

Sujet: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described.

Synonyms: 1C07_HUMAN antibody|Cw-7 alpha chain antibody|D6S204 antibody|HLA class I histocompatibility antigen antibody|HLA class I histocompatibility antigen, C alpha chain antibody|HLA class I histocompatibility antigen, Cw-1 alpha chain antibody|HLA-C antibodyHLA-C histocompatibility type antibody|HLA-Cw antibody|HLA-JY3 antibody|HLAC antibody|HLC-C antibody|human leukocyte antigen-C alpha chain antibody|major histocompatibility antigen HLA-C antibody|major histocompatibility complex, class I, C antibody|MHC class I antigen antibody|MHC class I antigen Cw 1 antibody|MHC class I antigen Cw*7 antibody|MHC class I antigen heavy chain HLA-C antibody|PSORS1 antibody

ID gène: 3107

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process