MAFA anticorps

N° du produit ABIN4951657

Détail du produit anti-MAFA anticorps

Antigène: MAFA (Transcription Factor MafA (MAFA))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAFA est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids EDAVEALIGSGHHGAHHGAHHPAAAAAYEAFR of human MAFA were used as the immunogen for the MAFA antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MAFA antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the MAFA antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur MAFA

Antigène: MAFA (Transcription Factor MafA (MAFA))

Autre désignation: MAFA (MAFA Produits)

Synonymes: anticorps RIPE3b1, anticorps hMafA, anticorps RGD1562627, anticorps 2F1-Ag, anticorps MAFA, anticorps MAFA-L, anticorps SMaf1, anticorps mafl, anticorps L-MAF, anticorps MAFL, anticorps Maf, anticorps v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian), anticorps MAF bZIP transcription factor A, anticorps killer cell lectin-like receptor subfamily G, member 1, anticorps v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A, anticorps v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa, anticorps monocyte to macrophage differentiation-associated, anticorps Mafa, anticorps MAFA, anticorps Klrg1, anticorps mafa, anticorps mafaa, anticorps Mmd

Sujet: MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA plays a key role in coordinating and controlling the level of insulin gene expression in islet beta cells. It is located in 8q24.3. The intracellular domain of MAFA contains a single immunoreceptor tyrosine-based inhibitory motif (ITIM), which classifies MAFA as a member of an inhibitory receptor superfamily. The inhibitory capacity of MAFA is best defined in mast cells, where MAFA keeps in check the antigen-induced (i.e. Fc epsilon RI-induced) secretion ofinflammatory mediators.

UniProt: Q8NHW3

Pathways: Hormone Transport