Bcl-2 anticorps (AA 144-171)
Aperçu rapide pour Bcl-2 anticorps (AA 144-171) (ABIN3030094)
Antigène
Voir toutes Bcl-2 (BCL2) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 144-171
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Réactivité croisée (Details)
- Expected species reactivity: Bovine, Chicken, Hamster, Mouse, Rat
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Purification
- Antigen affinity purified
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Immunogène
- A portion of amino acids 144-171 from the human protein was used as the immunogen for this Bcl-2 antibody.
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Isotype
- Ig Fraction
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Indications d'application
- The stated application concentrations are suggested starting amounts. Titration of the Bcl-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Can be stored at 4°C for one month. For long term, aliquot the Bcl-2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
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Autre désignation
- Bcl-2
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Sujet
- Bcl-2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). [UniProt]
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UniProt
- P10415
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Pathways
- Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Antigène
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