BAX anticorps (AA 41-76)

N° du produit ABIN3030145

Cet anticorps Lapin Polyclonal détecte spécifiquement BAX dans WB, IHC, ELISA et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour BAX anticorps (AA 41-76) (ABIN3030145)

Antigène: BAX (BCL2-Associated X Protein (BAX))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAX est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Détail du produit anti-BAX anticorps

Épitope: AA 41-76

Réactivité croisée (Details): Expected species reactivity: Bovine

Purification: Purified

Immunogène: A portion of amino acids 41-76 (BH3 domain) from the human protein was used as the immunogen for this Bax antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Bax antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Bax antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur BAX

Antigène: BAX (BCL2-Associated X Protein (BAX))

Autre désignation: Bax

Sujet: Bax belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bax forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of the Bax gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.

UniProt: Q07812

Pathways: Signalisation p53, Signalisation PI3K-Akt, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response