IL12 anticorps (AA 168-195)

N° du produit ABIN3031445

Détail du produit anti-IL12 anticorps

Antigène: IL12 (Interleukin 12 (IL12))

Épitope: AA 168-195

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL12 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC)

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 168-195 from the human protein was used as the immunogen for this IL-12 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the IL-12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the IL-12 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur IL12

Antigène: IL12 (Interleukin 12 (IL12))

Autre désignation: IL-12 (IL12 Produits)

Synonymes: anticorps CLMF, anticorps CLMF2, anticorps IL-12B, anticorps NKSF, anticorps NKSF2, anticorps p40, anticorps Il-12b, anticorps Il12p40, anticorps Il-12p40, anticorps Il12, anticorps IL-12p40, anticorps IL-12, anticorps LOC100217488, anticorps IL-12p35, anticorps Il-12a, anticorps Ll12a, anticorps p35, anticorps IL12p40, anticorps IL12B, anticorps IL-12 p35, anticorps interleukin 12B, anticorps interleukin 12A, anticorps interleukin 12b, anticorps interleukin 12a, anticorps Interleukin 12 level, anticorps IL12B, anticorps IL12A, anticorps Il12b, anticorps Il12a, anticorps IL12, anticorps il12a

Sujet: IL12A is a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.

UniProt: P29459

Pathways: Signalistation JAK/STAT, Signalisation TLR, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome