Insulin Receptor anticorps (AA 21-52)

N° du produit ABIN3031335

Cet anticorps anti-Insulin Receptor est un anticorps Lapin Polyclonal détectant Insulin Receptor dans WB, IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour Insulin Receptor anticorps (AA 21-52) (ABIN3031335)

Antigène: Insulin Receptor (INSR)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Insulin Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-Insulin Receptor anticorps

Épitope: AA 21-52

Réactivité croisée (Details): Expected species reactivity: Mouse, Rat

Purification: Purified

Immunogène: A portion of amino acids 21-52 from the human protein was used as the immunogen for this Insulin Receptor antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Insulin Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Insulin Receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur Insulin Receptor

Antigène: Insulin Receptor (INSR)

Autre désignation: Insulin Receptor

Sujet: INSR binds insulin and has a tyrosine-protein kinase activity. Autophosphorylation activates the kinase activity. This Type I mebrane protein is composed of a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. After being transported from the endoplasmic reticulum to the Golgi apparatus, the single glycosylated precursor is further glycosylated and then cleaved, followed by its transport to the plasma membrane.

UniProt: P06213

Pathways: Signalisation NF-kappaB, Signalisation RTK, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity