LRP2 anticorps (AA 4626-4655)

N° du produit ABIN3031639

Cet anticorps Lapin Polyclonal détecte spécifiquement LRP2 dans ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour LRP2 anticorps (AA 4626-4655) (ABIN3031639)

Antigène: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-LRP2 anticorps

Épitope: AA 4626-4655

Purification: Purified

Immunogène: A portion of amino acids 4626-4655 from the human protein was used as the immunogen for this Megalin antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the Megalin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. IHC (Paraffin): 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Megalin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur LRP2

Antigène: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Autre désignation: Megalin

Sujet: Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration (1). Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes (2). All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family (3).

UniProt: P98164

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport