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SQSTM1 anticorps (AA 317-346)

SQSTM1 Reactivité: Humain, Green Monkey WB, IHC, IF, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN3031543
  • Antigène Voir toutes SQSTM1 Anticorps
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Épitope
    • 19
    • 17
    • 15
    • 13
    • 11
    • 11
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 317-346
    Reactivité
    • 171
    • 64
    • 61
    • 18
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Green Monkey
    Hôte
    • 145
    • 24
    • 1
    • 1
    Lapin
    Clonalité
    • 144
    • 27
    Polyclonal
    Conjugué
    • 77
    • 13
    • 12
    • 8
    • 8
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SQSTM1 est non-conjugé
    Application
    • 121
    • 57
    • 49
    • 39
    • 25
    • 23
    • 18
    • 16
    • 14
    • 13
    • 10
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA
    Réactivité croisée (Details)
    Expected species reactivity: Mouse, Rat
    Purification
    Antigen affinity purified
    Immunogène
    A portion of amino acids 317-346 from the human protein was used as the immunogen for this p62 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SQSTM1 Anticorps primaire
  • Indications d'application
    Titration of the p62 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS pH 7.4 with 0.09 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Aliquot the p62 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Antigène
    SQSTM1 (Sequestosome 1 (SQSTM1))
    Autre désignation
    p62 (SQSTM1) (SQSTM1 Produits)
    Synonymes
    anticorps SQSTM1, anticorps sqstm1, anticorps MGC79491, anticorps A170, anticorps OSIL, anticorps PDB3, anticorps ZIP3, anticorps p60, anticorps p62, anticorps p62B, anticorps OSF-6, anticorps Osi, anticorps STAP, anticorps ZIP, anticorps sb:cb621, anticorps zgc:85784, anticorps sequestosome 1, anticorps sequestosome 1 L homeolog, anticorps SQSTM1, anticorps sqstm1, anticorps Sqstm1, anticorps sqstm1.L
    Sujet
    SQSTM1/p62 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. This protein may play a role in titin/TTN downstream signaling in muscle cells, and may also regulate signaling cascades through ubiquitination. This protein is involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. SQSTM1/p62 also appears to play a role in macroautophagic removal of intracellular protein aggregates. Cellular depletion studies of SQSTM1/p62 have indicated a role for association with LC3 and aggregate proteins in order to facilitate normal formation of the autophagosome.
    UniProt
    Q13501
    Pathways
    Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Autophagy
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