EIF2AK2 anticorps (AA 11-42)

N° du produit ABIN3030884

L’anticorps anti-EIF2AK2 Polyclonal Lapin est utilisé pour la détection de EIF2AK2 dans des échantillons de Humain et Souris. Il a été validé pour WB, IHC et ELISA.

Aperçu rapide pour EIF2AK2 anticorps (AA 11-42) (ABIN3030884)

Antigène: EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF2AK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-EIF2AK2 anticorps

Épitope: AA 11-42

Fonction: PKR Antibody

Purification: Purified

Immunogène: A portion of amino acids 11-42 from the human protein was used as the immunogen for this PKR antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the PKR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles

Stock: -20 °C

Stockage commentaire: Aliquot the PKR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur EIF2AK2

Antigène: EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))

Autre désignation: PKR

Sujet: Interferon-induced, double-stranded RNA-activated protein kinase (PRKR/PKR) is a serine-threonine kinase. Activation by dsRNAs leads to autophosphorylation of PKR and allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha), leading to the inhibition of protein synthesis. PRKR, which is involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, activates IKK and NFKB, thereby suppressing apoptosis. Apoptosis induced by live pathogenic gram-positive and gram-negative bacteria requirs both TLR4 and PKR, possibly representing a major mechanism for pathogenic bacteria that use specific virulence factors to avoid detection and destruction by the innate immune system.

UniProt: P19525

Pathways: Réparation de l'ADN, ER-Nucleus Signaling, Hepatitis C