ROR2 anticorps (AA 19-50)

N° du produit ABIN3032442

Cet anticorps anti-ROR2 est un anticorps Lapin Polyclonal détectant ROR2 dans WB, IHC, ELISA et FACS. Adapté pour Humain.

Aperçu rapide pour ROR2 anticorps (AA 19-50) (ABIN3032442)

Antigène: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROR2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Détail du produit anti-ROR2 anticorps

Épitope: AA 19-50

Purification: Purified

Immunogène: A portion of amino acids 19-50 from the human protein was used as the immunogen for this ROR2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the ROR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the ROR2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur ROR2

Antigène: ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))

Autre désignation: ROR2

Sujet: ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed. Defects in ROR2 are a cause of recessive Robinow syndrome (RRS). RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance. The protein contains 1 frizzled (FZ) domain, 1 immunoglobulin-like C2-type domain, and 1 kringle domain.

UniProt: Q01974

Pathways: Signalisation RTK, Signalisation WNT