SUV39H2 anticorps (AA 367-395)

N° du produit ABIN3029053

Cet anticorps Lapin Polyclonal détecte spécifiquement SUV39H2 dans WB et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour SUV39H2 anticorps (AA 367-395) (ABIN3029053)

Antigène: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUV39H2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SUV39H2 anticorps

Épitope: AA 367-395

Réactivité croisée (Details): Expected species reactivity: Mouse, Primate

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 367-395 from the human protein was used as the immunogen for this SUV39H2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the SUV39H2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SUV39H2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur SUV39H2

Antigène: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Autre désignation: SUV39H2 (KTM1B)

Sujet: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.

UniProt: Q9H5I1