Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps STAT5, anticorps stat5, anticorps STAT5A, anticorps STAT5B, anticorps signal transducer and activator of transcription 5B, anticorps signal transducer and activator of transcription 5B S homeolog, anticorps Signal transducer and activator of transcription 5B, anticorps STAT5B, anticorps Stat5b, anticorps stat5b.S, anticorps LOC490969, anticorps sta5b, anticorps LOC100566752, anticorps LOC100052954
Sujet
Stat5a and Stat5b (signal transducer and activator of transcription 5a and 5b, 96 % homology) undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser 127/Ser 128 and Ser 779 are contigent on ErbB4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with retinoic acid receptor-α gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.Synonyms: STAT-5B, Signal transducer and activator of transcription 5B