RASGRF1 anticorps
-
- Antigène Voir toutes RASGRF1 Anticorps
- RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1))
-
Reactivité
- Souris, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp RASGRF1 est non-conjugé
-
Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- This antibody detects endogenous levels of Ras-GRF1 protein.
- Réactivité croisée (Details)
- Species reactivity (tested):Mouse and Rat.
- Purification
- Affinity chromatography using epitope-specific immunogen
- Pureté
- > 95 % (by SDS-PAGE)
- Top Product
- Discover our top product RASGRF1 Anticorps primaire
-
-
- Indications d'application
-
Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
-
- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
-
- Antigène
- RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1))
- Autre désignation
- RASGRF1 (RASGRF1 Produits)
- Synonymes
- anticorps CDC25, anticorps CDC25L, anticorps GNRP, anticorps GRF1, anticorps GRF55, anticorps H-GRF55, anticorps PP13187, anticorps ras-GRF1, anticorps AI844718, anticorps CDC25Mm, anticorps Grf1, anticorps Grfbeta, anticorps P190-A, anticorps Ras-GRF1, anticorps p190, anticorps p190RhoGEF, anticorps cdc25, anticorps rasgrf1, anticorps Ras protein specific guanine nucleotide releasing factor 1, anticorps RAS protein-specific guanine nucleotide-releasing factor 1, anticorps Ras protein specific guanine nucleotide releasing factor 1 S homeolog, anticorps si:ch211-234p18.3, anticorps RASGRF1, anticorps Rasgrf1, anticorps rasgrf1.S, anticorps si:ch211-234p18.3, anticorps rasgrf1
- Sujet
- A critical step in signal transduction responses to stimulation of cell surface receptors by their ligands involves the accumulation of Ras proteins in their active GTP-bound state. To reach their active GTP-bound state, Ras proteins must first release bound GDP, a rate limiting step mediated by a guanine nucleotide releasing factor (GRF). The mammalian Ras p21 GRF protein has been designated Ras-GRF1 p140. Ras-GRF1 accelerates release of GDP from H- and N-Ras p21 protein in vitro, but not from the related Ral A or Cdc42Hs GTP-binding proteins. Of interest, a region mapping within the amino terminal domain of Ras-GRF1 is similar to both the human breakpoint cluster protein, Bcr, and the Dbl proto-oncogene product, a guanine nucleotide-releasing factor for Cdc42Hs. Ras-GRF2 p135 has also been identified. Ras-GRF2 p135 is highly homologous to Ras-GRF1 p140 except in the region between the REM and CDC25 domains and appears to function similarly to Ras-GRF1 p140.Synonyms: CDC25, GNRP, GRF1, Guanine nucleotide-releasing protein, Ras-GRF1, Ras-specific guanine nucleotide-releasing factor 1, Ras-specific nucleotide exchange factor CDC25
- ID gène
- 19417
- NCBI Accession
- NP_035375
- UniProt
- P27671
- Pathways
- Signalisation RTK, Cycle Cellulaire, M Phase
-