MALT1 anticorps

N° du produit ABIN498450

Détail du produit anti-MALT1 anticorps

Antigène: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MALT1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of MALT1 protein. (region surrounding asn324)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur MALT1

Antigène: MALT1 (Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1 (MALT1))

Autre désignation: MALT1 (MALT1 Produits)

Synonymes: anticorps malt1, anticorps MALT1, anticorps mlt, anticorps mlt1, anticorps MLT, anticorps MLT1, anticorps A630046N12, anticorps D430033E09Rik, anticorps MALT paracaspase 2, anticorps MALT1 paracaspase, anticorps MALT1 paracaspase S homeolog, anticorps paracaspase 3, anticorps malt2, anticorps MALT1, anticorps malt1.S, anticorps Malt1, anticorps PCASP3

Sujet: Mucosa Associated Lymphoid Tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B-cell lymphomas. MALT1 encodes two Iglike C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11,18)(q21,q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. The MALT1-API2 fusion protein activates NF-kappaB and creates a signaling pathway, which is influenced by this Bcl10-MALT1 complex. MALT1 mRNA is found in pre-B cells, mature B cells, and plasma cells.Synonyms: MALT lymphoma-associated translocation, MLT, Mucosa-associated lymphoid tissue lymphoma translocation protein 1, Paracaspase

Poids moléculaire: approx. 68 kDa

ID gène: 10892

NCBI Accession: NP_006776

UniProt: Q9UDY8

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins