BNIP2 anticorps

N° du produit ABIN498505

Détail du produit anti-BNIP2 anticorps

Antigène: BNIP2 (BCL2/adenovirus E1B 19kDa Interacting Protein 2 (BNIP2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BNIP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of BNIP-2 protein. (region surrounding Glu122)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur BNIP2

Antigène: BNIP2 (BCL2/adenovirus E1B 19kDa Interacting Protein 2 (BNIP2))

Autre désignation: BNIP2 (BNIP2 Produits)

Synonymes: anticorps BNIP-2, anticorps NIP2, anticorps 5730523P12Rik, anticorps BNIP2beta, anticorps Nip21, anticorps BCL2 interacting protein 2, anticorps BCL2/adenovirus E1B interacting protein 2, anticorps BNIP2, anticorps Bnip2

Sujet: The adenovirus E1B protein is a viral homolog of the Bcl-2 family of proteins that are involved in regulating cell death. A family of interacting proteins, which are designated Nip or Bnip and include BNIP-1, BNIP-2, BNIP-3 and Nix, associate with both the E1B protein and Bcl-2 proteins to mediate apoptotic signaling. BNIP-1 contains a hydrophobic transmembrane domain, which enables its localization to the nuclear envelope, endoplasmic recticulum and mitochondria. BNIP-2, (previously designated Nip2 and Nip21 in human and mouse respectively), shares homology with the non-catalytic domain of Cdc42 GTPase-activating protein (Cdc42GAP). Through binding to Cdc42GAP, BNIP-2 enhances the GTPase activity of Cdc42GAP, facilitating the hydrolysis of GTP bound to Cdc42 and thereby, mediating the signaling pathways involving receptor kinases, small GTPases and apoptotic proteins. Nix, which is also designated Nip3L or Bnip3L, is highly related to BNIP-3, and both proteins localize to the mitochondria where they associate with Bcl-2 proteins.Synonyms: BCL2/adenovirus E1B 19 kDa protein-interacting protein 2, NIP2

Poids moléculaire: approx. 34 kDa

ID gène: 663

NCBI Accession: NP_004321

UniProt: Q12982

Pathways: Regulation of Muscle Cell Differentiation