MEIS1 anticorps

N° du produit ABIN498509

Détail du produit anti-MEIS1 anticorps

Antigène: MEIS1 (Meis Homeobox 1 (MEIS1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MEIS1 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects endogenous levels of Meis1 protein. (region surrounding Ile278)

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse.

Purification: Affinity chromatography

Pureté: > 95 % by SDS-PAGE

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur MEIS1

Antigène: MEIS1 (Meis Homeobox 1 (MEIS1))

Autre désignation: MEIS1 (MEIS1 Produits)

Synonymes: anticorps meis, anticorps 1323/07, anticorps 1422/04, anticorps CG17117, anticorps Dm-HTH, anticorps Dmel\\CG17117, anticorps HTH, anticorps Hth, anticorps Meis1, anticorps P53, anticorps anon-EST:Liang-2.13, anticorps clone 2.13, anticorps dtl, anticorps hth1, anticorps hth2, anticorps l(3)05745, anticorps l(3)86Ca, anticorps cb224, anticorps id:ibd5078, anticorps meis1.1, anticorps wu:fb38b03, anticorps wu:fc02e11, anticorps wu:fd12a02, anticorps C530044H18Rik, anticorps Evi8, anticorps Meis homeobox 1, anticorps Meis homeobox 1 S homeolog, anticorps homothorax, anticorps Meis homeobox 1 b, anticorps MEIS1, anticorps meis1.S, anticorps Meis1, anticorps hth, anticorps meis1b, anticorps meis1

Sujet: Hox, Pbx, and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Hox proteins are involved in regulating tissue patterning during development, and they are also expressed n lineage- and stage-specific patterns during adult ematopoietic ifferentiation and in leukemias. The Hox proteins, which include paralog groups 1 to 10, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx related Meis proteins, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site. Both Meis1 and 2 (also known as Meis-related gene 1) are members of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. In addition to binding with Hox proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, including Pbx1, Pbx2 and Pbx3, and these complexes contain distinct DNA-binding specificities.Synonyms: Homeobox protein Meis1

Poids moléculaire: approx. 37 kDa

ID gène: 4211

NCBI Accession: NP_002389

UniProt: O00470

Pathways: Chromatin Binding