RSPO1 anticorps (N-Term)

N° du produit ABIN500638

Cet anticorps Lapin Polyclonal détecte spécifiquement RSPO1 dans WB, IHC (p) et EIA. Il présente une réactivité envers Humain, Rat et Souris.

Aperçu rapide pour RSPO1 anticorps (N-Term) (ABIN500638)

Antigène: RSPO1 (R-Spondin 1 (RSPO1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RSPO1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Détail du produit anti-RSPO1 anticorps

Épitope: N-Term

Specificité: This antibody detects RSPO1. It will not cross-react with RSPO family members.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: RSPO1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human RSPO1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur RSPO1

Antigène: RSPO1 (R-Spondin 1 (RSPO1))

Autre désignation: RSPO1

Sujet: RSPO1 is a member of a family of secreted growth factors that can operate through the canonical Wnt signaling pathway by stabilizing the intracellular b-catenin, thereby regulating functions mediated by b-catenin such as cell fate decisions and embryonic patterning. RSPO1 was recently identified through linkage analysis to be involved in sex determination and mammalian ovarian development. RSPO1 is thought to regulate cellular responsiveness to Wnt ligands by modulating the cell-surface expression of the Wnt co-receptor LRP6 by interfering with the DKK/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 cell-surface levels. At least two isoforms of RSPO1 are known to exist.Synonyms: R-spondin-1, Roof plate-specific spondin-1

ID gène: 284654

NCBI Accession: NP_001033722

UniProt: Q2MKA7