SKI anticorps (N-Term)

N° du produit ABIN500734

Détail du produit anti-SKI anticorps

Antigène: SKI (SKI Proto-Oncogene (SKI))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SKI est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody detects Ski. it will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogène: Ski antibody was raised against a 14 amino acid peptide from near the amino terminus of human Ski.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunoflourescence.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur SKI

Antigène: SKI (SKI Proto-Oncogene (SKI))

Autre désignation: SKI (SKI Produits)

Synonymes: anticorps SGS, anticorps SKV, anticorps SKI, anticorps C-SKI, anticorps RGD1565591, anticorps c-ski, anticorps 2310012I02Rik, anticorps 2610001A11Rik, anticorps AA062172, anticorps AA589460, anticorps BC004088, anticorps ski, anticorps skv, anticorps xski, anticorps id:ibd1250, anticorps SKI proto-oncogene, anticorps ski sarcoma viral oncogene homolog (avian), anticorps SKI proto-oncogene L homeolog, anticorps v-ski avian sarcoma viral oncogene homolog a, anticorps SKI, anticorps Ski, anticorps ski.L, anticorps skia

Sujet: TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes.Synonyms: Proto-oncogene c-Ski, Ski oncogene, ski oncoprotein, v-ski avian sarcoma viral oncogene homolog

ID gène: 6497

UniProt: P12755

Pathways: Stem Cell Maintenance, Tube Formation, Skeletal Muscle Fiber Development